Hematopoietic chimerism remains the most promising strategy to bring transplantation
tolerance into clinical routine. The concept of chimerism-based tolerance aims to extend the …

Induction of allograft tolerance has been considered the ultimate goal in organ
transplantation. Although numerous protocols to induce allograft tolerance have been …

Although lung transplant is a life-saving therapy for some patients, primary graft dysfunction
(PGD) is a leading cause of mortality and morbidity soon after a transplant. Ischemia …

Cynomolgus monkeys as nonhuman primates are valuable animal models because they
have a high level of human gene homology. There are many reference values for …

While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts
in nonhuman primates and patients, this approach has not been successful for more …

The present review discusses current developments in tolerance induction for solid organ
transplantation with a particular emphasis on chimerism-based approaches. It explains the …

Successful induction of allograft tolerance has been achieved in nonhuman primates
(NHPs) and humans via induction of transient hematopoietic chimerism. Since allograft …

Lung transplantation is the only treatment for end-stage lung disease; however, donor organ
shortage and intense immunosuppression limit its broad clinical impact. Bioengineering of …

Rhesus macaque is an important animal model in biomedical research, especially human
disease, developmental, translational, and pre-clinical research. Blood physiological and …

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP)
models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary …