The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …

Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the
development of obesity/diabetes mellitus–induced cardiomyopathy. However, enhancing …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory
mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was …

The widely expressed transmembrane glycoprotein, cluster of differentiation 36 (CD36), a
scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …