Current concepts of psoriasis immunopathogenesis

M Vičić, M Kaštelan, I Brajac, V Sotošek… - International Journal of …, 2021 - mdpi.com
Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the
skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is …

Skin barrier dysregulation in psoriasis

A Orsmond, L Bereza-Malcolm, T Lynch… - International journal of …, 2021 - mdpi.com
The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

RNA m6A demethylase ALKBH5 regulates the development of γδ T cells

C Ding, H Xu, Z Yu, M Roulis, R Qu… - Proceedings of the …, 2022 - National Acad Sciences
γδ T cells are an abundant T cell population at the mucosa and are important in providing
immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T …

The role of γδ T cells in the immunopathogenesis of inflammatory diseases: from basic biology to therapeutic targeting

B Bernal-Alferes, R Gómez-Mosqueira… - Journal of Leukocyte …, 2023 - academic.oup.com
The γδ T cells are lymphocytes with an innate-like phenotype that can distribute to different
tissues to reside and participate in homeostatic functions such as pathogen defense, tissue …

MAIT cells in immune‐mediated tissue injury and repair

A Waterhölter, M Wunderlich… - European Journal of …, 2023 - Wiley Online Library
Mucosal‐associated invariant T (MAIT) cells are T cells that express a semi‐invariant αβ T‐
cell receptor (TCR), recognizing non‐peptide antigens, such as microbial‐derived vitamin …

Characterization of the TCRβ repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients

M Jirouš Drulak, Z Grgić, V Plužarić, M Šola… - Scientific reports, 2023 - nature.com
Psoriasis vulgaris (PV) is an inflammatory skin disease largely driven by aberrant αβT cells.
Mucosal-associated invariant T (MAIT) cells, which constitute the largest circulating innate …

N6‐ Methyladenosine defines a new checkpoint in γδ T cell development

J Zhao, C Ding, HB Li - BioEssays, 2023 - Wiley Online Library
T cells, which are derived from hematopoietic stem cells (HSCs), are the most important
components of adaptive immune system. Based on the expression of αβ and γδ receptors, T …

The miR-20a/miR-92b Profile Is Associated with Circulating γδ T-Cell Perturbations in Mild Psoriasis

S Tokić, M Jirouš, V Plužarić, M Mihalj, M Šola… - International journal of …, 2023 - mdpi.com
Psoriasis vulgaris (PV) is an autoinflammatory dermatosis of unknown etiology. Current
evidence suggests a pathogenic role of γδT cells, but the growing complexity of this …

[PDF][PDF] Identifying Candidate Biomarkers of Clinical Response to Ustekinumab in Psoriasis

S Solanky - 2024 - kclpure.kcl.ac.uk
The development and use of biologic drugs, including ustekinumab, secukinumab,
adalimumab and newer anti-interleukin (IL)-23p19 biologics, have revolutionised treatment …

DOPRINOS GAMMA DELTA (ɣδ) T-LIMFOCITA U RAZVOJU TIPA 2 UPALE U SINONAZALNOJ SLUZNICI OBOLJELIH OD KRONIČNOG ALERGIJSKOG …

S Grga Milanković - 2024 - repozitorij.ds.unios.hr
Metodom protočne citometrije zabilježena je povećana distribucija subpopulacija δ1-δ2-γδ
T-limfocita u sinonazalnoj sluznici bolesnika s eKRSsNP. Također, metodom RT-qPCR …