Carbohydrate-active enzymes (CAZymes) in the gut microbiome

JF Wardman, RK Bains, P Rahfeld… - Nature Reviews …, 2022 - nature.com
The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

[HTML][HTML] Amino assets: how amino acids support immunity

B Kelly, EL Pearce - Cell metabolism, 2020 - cell.com
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

[HTML][HTML] Structural and mechanistic insights into fungal β-1, 3-glucan synthase FKS1

X Hu, P Yang, C Chai, J Liu, H Sun, Y Wu, M Zhang… - Nature, 2023 - nature.com
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1, 3-glucan, the
core component of the fungal cell wall,. FKS is the target of widely prescribed antifungal …

[HTML][HTML] A review of the molecular mechanisms of acaricide resistance in mites and ticks

S De Rouck, E İnak, W Dermauw… - Insect Biochemistry and …, 2023 - Elsevier
Abstract The Arachnida subclass of Acari comprises many harmful pests that threaten
agriculture as well as animal health, including herbivorous spider mites, the bee parasite …

[HTML][HTML] Insights into the role of sialylation in cancer progression and metastasis

C Dobie, D Skropeta - British Journal of Cancer, 2021 - nature.com
Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

[HTML][HTML] Structural basis for directional chitin biosynthesis

W Chen, P Cao, Y Liu, A Yu, D Wang, L Chen… - Nature, 2022 - nature.com
Chitin, the most abundant aminopolysaccharide in nature, is an extracellular polymer
consisting of N-acetylglucosamine (GlcNAc) units. The key reactions of chitin biosynthesis …

Assembly of bacterial capsular polysaccharides and exopolysaccharides

C Whitfield, SS Wear, C Sande - Annual Review of Microbiology, 2020 - annualreviews.org
Polysaccharides are dominant features of most bacterial surfaces and are displayed in
different formats. Many bacteria produce abundant long-chain capsular polysaccharides …

Catalytic approaches to chemo-and site-selective transformation of carbohydrates

K Yamatsugu, M Kanai - Chemical Reviews, 2023 - ACS Publications
Carbohydrates are a fundamental unit playing pivotal roles in all the biological processes. It
is thus essential to develop methods for synthesizing, functionalizing, and manipulating …

Lignocellulose degradation: An overview of fungi and fungal enzymes involved in lignocellulose degradation

M Andlar, T Rezić, N Marđetko… - Engineering in life …, 2018 - Wiley Online Library
This review aims to present current knowledge of the fungi involved in lignocellulose
degradation with an overview of the various classes of lignocellulose‐acting enzymes …

Structure, substrate recognition and initiation of hyaluronan synthase

FP Maloney, J Kuklewicz, RA Corey, Y Bi, R Ho… - Nature, 2022 - nature.com
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine
and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular …