Immune-checkpoint inhibition provides an unmatched level of durable clinical efficacy in
various malignancies. Such therapies promote the activation of antigen-specific T cells …

Cancer immunotherapies have made much headway during the past decades. Techniques
including the immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT) have …

The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune …

Background We assessed the safety, efficacy, and pharmacokinetics of the transforming
growth factor beta (TGFβ) receptor inhibitor galunisertib co-administered with the anti …

Checkpoint proteins are an integral part of the immune system and are used by the tumor
cells to evade immune response, which helps them grow uncontrollably. By blocking these …

Astatine-211 (211At) has physical properties that make it one of the top candidates for use
as a radiation source for alpha particle-based radionuclide therapy, also referred to as …

Microsatellite instability (MSI) has been identified in several tumors arising from either
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …

Genetic alterations, especially the K-Ras mutation, carry the heaviest burden in the
progression of pancreatic precursor lesions into pancreatic ductal adenocarcinoma (PDAC) …

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …

The development of immune checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte
antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), or programmed cell death …