Brain ischemia: CT and MRI techniques in acute ischemic stroke

P Vilela, HA Rowley - European journal of radiology, 2017 - Elsevier
Imaging plays a central role for intravenous and intra-arterial arterial ischemic stroke
treatment patient selection. Computed tomography (CT)/CT angiography or magnetic …

Automated CT perfusion imaging for acute ischemic stroke: pearls and pitfalls for real-world use

A Vagal, M Wintermark, K Nael, A Bivard, M Parsons… - Neurology, 2019 - AAN Enterprises
Recent positive trials have thrust acute cerebral perfusion imaging into the routine
evaluation of acute ischemic stroke. Updated guidelines state that in patients with anterior …

Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study

X Huang, BK Cheripelli, SM Lloyd, D Kalladka… - The Lancet …, 2015 - thelancet.com
Background In most countries, alteplase given within 4· 5 h of onset is the only approved
medical treatment for acute ischaemic stroke. The newer thrombolytic drug tenecteplase has …

Cerebral small vessel disease: capillary pathways to stroke and cognitive decline

L Østergaard, TS Engedal, F Moreton… - Journal of Cerebral …, 2016 - journals.sagepub.com
Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and
constitutes a major source of cognitive decline in the elderly. SVD is known to occur in …

Whole-brain CT perfusion to quantify acute ischemic penumbra and core

L Lin, A Bivard, V Krishnamurthy, CR Levi, MW Parsons - Radiology, 2016 - pubs.rsna.org
Purpose To validate the use of perfusion computed tomography (CT) with whole-brain
coverage to measure the ischemic penumbra and core and to compare its performance to …

Computer-aided imaging analysis in acute ischemic stroke–background and clinical applications

Y Mokli, J Pfaff, DP Dos Santos, C Herweh… - … research and practice, 2019 - Springer
Tools for medical image analysis have been developed to reduce the time needed to detect
abnormalities and to provide more accurate results. Particularly, tools based on artificial …

Perfusion computed tomography for the evaluation of acute ischemic stroke: strengths and pitfalls

JJ Heit, M Wintermark - Stroke, 2016 - Am Heart Assoc
Figure 1. Matched and Mismatched perfusion computed tomography (PCT) imaging in a
patient with middle cerebral artery (MCA) occlusions. Noncontrast head CT (NCCT) and …

Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom

K Kudo, S Christensen, M Sasaki, L Østergaard… - Radiology, 2013 - pubs.rsna.org
Purpose To design a digital phantom data set for computed tomography (CT) perfusion and
perfusion-weighted imaging on the basis of the widely accepted tracer kinetic theory in …

Computed tomography–based quantification of lesion water uptake identifies patients within 4.5 hours of stroke onset: a multicenter observational study

J Minnerup, G Broocks, J Kalkoffen… - Annals of …, 2016 - Wiley Online Library
Objective Many patients with stroke cannot receive intravenous thrombolysis because the
time of symptom onset is unknown. We tested whether computed tomography (CT)‐based …

Defining core and penumbra in ischemic stroke: a voxel-and volume-based analysis of whole brain CT perfusion

Y Yu, Q Han, X Ding, Q Chen, K Ye, S Zhang, S Yan… - Scientific reports, 2016 - nature.com
Whole brain computed tomography perfusion (CTP) has the potential to select eligible
patients for reperfusion therapy. We aimed to find the optimal thresholds on baseline CTP for …