Artificial intelligence, machine learning, and drug repurposing in cancer
Z Tanoli, M Vähä-Koskela… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction: Drug repurposing provides a cost-effective strategy to re-use approved drugs
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …
Function of lipid binding proteins of parasitic helminths: still a long road
JF Lombardo, JL Pórfido, MS Sisti, AN Giorello… - Parasitology …, 2022 - Springer
Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases
in humans and domestic animals on a global scale. Unable to synthesize de novo their own …
in humans and domestic animals on a global scale. Unable to synthesize de novo their own …
[HTML][HTML] Proteomic analysis of Taenia solium cysticercus and adult stages
L Li, W He, X Fan, M Liu, B Luo, F Yang… - Frontiers in Veterinary …, 2023 - frontiersin.org
Taenia solium (T. solium) cysticercosis is a neglected parasitic zoonosis that occurs in
developing countries. Since T. solium has a complex life cycle that includes eggs …
developing countries. Since T. solium has a complex life cycle that includes eggs …
[HTML][HTML] Molecular Characteristics of the Fatty-Acid-Binding Protein (FABP) Family in Spirometra mansoni―A Neglected Medical Tapeworm
S Liu, F Gao, R Wang, W Li, S Wang, X Zhang - Animals, 2023 - mdpi.com
Simple Summary The purpose of this study was to investigate the members, gene
expression patterns, and molecular characteristics of the Spirometra mansoni fatty-acid …
expression patterns, and molecular characteristics of the Spirometra mansoni fatty-acid …
[HTML][HTML] Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease
The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to
rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and …
rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and …
Investigating the Taenia solium Fatty Acid Binding Protein Superfamily for Their Immunological Outlook and Prospect for Therapeutic Targets
Taenia solium, like other helminthic parasites, lacks key components of cellular machinery
required for endogenous lipid biosynthesis. This deficiency compels the parasite to obtain …
required for endogenous lipid biosynthesis. This deficiency compels the parasite to obtain …
[HTML][HTML] Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro
SM Ruatta, DN Prada Gori, M Fló Díaz… - Frontiers in …, 2023 - frontiersin.org
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2
replication continues to be a priority in several academic and pharmaceutical laboratories …
replication continues to be a priority in several academic and pharmaceutical laboratories …
Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages
X Li, P Liao, W Zhou, X Yang, B Ye - Acta Tropica, 2024 - Elsevier
Fatty acid binding proteins (FABPs) have emerged as attractive vaccination candidates for
several platyhelminth species. To explore the physiological functions of Echinococcus …
several platyhelminth species. To explore the physiological functions of Echinococcus …
Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1
MA Llanos, LN Alberca, SCV Larrea… - Chemistry & …, 2022 - Wiley Online Library
Cyclic nucleotide phosphodiesterases have been implicated in the proliferation,
differentiation and osmotic regulation of trypanosomatids; in some trypanosomatid species …
differentiation and osmotic regulation of trypanosomatids; in some trypanosomatid species …
[HTML][HTML] In silico analysis of the action of saturated, monounsaturated, and polyunsaturated fatty acids against Echinococcus granulosus fatty-acid …
M Paco-Chipana, K Mena-Ulecia… - …, 2024 - f1000research.com
Background The zoonotic infection caused by tapeworms Echinococcus is a neglected
tropical disease in poor regions with limited access to suitable sanitary conditions. Hydatid …
tropical disease in poor regions with limited access to suitable sanitary conditions. Hydatid …