Artificial intelligence, machine learning, and drug repurposing in cancer

Z Tanoli, M Vähä-Koskela… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction: Drug repurposing provides a cost-effective strategy to re-use approved drugs
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …

Function of lipid binding proteins of parasitic helminths: still a long road

JF Lombardo, JL Pórfido, MS Sisti, AN Giorello… - Parasitology …, 2022 - Springer
Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases
in humans and domestic animals on a global scale. Unable to synthesize de novo their own …

[HTML][HTML] Proteomic analysis of Taenia solium cysticercus and adult stages

L Li, W He, X Fan, M Liu, B Luo, F Yang… - Frontiers in Veterinary …, 2023 - frontiersin.org
Taenia solium (T. solium) cysticercosis is a neglected parasitic zoonosis that occurs in
developing countries. Since T. solium has a complex life cycle that includes eggs …

[HTML][HTML] Molecular Characteristics of the Fatty-Acid-Binding Protein (FABP) Family in Spirometra mansoni―A Neglected Medical Tapeworm

S Liu, F Gao, R Wang, W Li, S Wang, X Zhang - Animals, 2023 - mdpi.com
Simple Summary The purpose of this study was to investigate the members, gene
expression patterns, and molecular characteristics of the Spirometra mansoni fatty-acid …

[HTML][HTML] Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease

DN Prada Gori, S Ruatta, M Fló, LN Alberca… - Frontiers in Drug …, 2023 - frontiersin.org
The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to
rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and …

Investigating the Taenia solium Fatty Acid Binding Protein Superfamily for Their Immunological Outlook and Prospect for Therapeutic Targets

SS Rawat, G Singh, A Prasad - ACS omega, 2024 - ACS Publications
Taenia solium, like other helminthic parasites, lacks key components of cellular machinery
required for endogenous lipid biosynthesis. This deficiency compels the parasite to obtain …

[HTML][HTML] Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro

SM Ruatta, DN Prada Gori, M Fló Díaz… - Frontiers in …, 2023 - frontiersin.org
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2
replication continues to be a priority in several academic and pharmaceutical laboratories …

Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

X Li, P Liao, W Zhou, X Yang, B Ye - Acta Tropica, 2024 - Elsevier
Fatty acid binding proteins (FABPs) have emerged as attractive vaccination candidates for
several platyhelminth species. To explore the physiological functions of Echinococcus …

Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1

MA Llanos, LN Alberca, SCV Larrea… - Chemistry & …, 2022 - Wiley Online Library
Cyclic nucleotide phosphodiesterases have been implicated in the proliferation,
differentiation and osmotic regulation of trypanosomatids; in some trypanosomatid species …

[HTML][HTML] In silico analysis of the action of saturated, monounsaturated, and polyunsaturated fatty acids against  Echinococcus granulosus fatty-acid …

M Paco-Chipana, K Mena-Ulecia… - …, 2024 - f1000research.com
Background The zoonotic infection caused by tapeworms Echinococcus is a neglected
tropical disease in poor regions with limited access to suitable sanitary conditions. Hydatid …