Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …

Modern genetic data combined with appropriate statistical methods have the potential to
contribute substantially to our understanding of human history. We have developed an …

The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in …

Haplotype-based methods offer a powerful approach to disease gene mapping, based on
the association between causal mutations and the ancestral haplotypes on which they …

Globally, 800 million people are malnourished. Heavily subsidised farmers in rich countries
produce sufficient surplus food to feed the hungry, but not at a price the poor can afford …

Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …

Inherited genetic variation has a critical but as yet largely uncharacterized role in human
disease. Here we report a public database of common variation in the human genome: more …

Meiotic recombination events cluster into narrow segments of the genome, defined as
hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 …

Future advances in plant genomics will make it possible to scan a genome for
polymorphisms associated with qualitative and quantitative traits. Before this potential can …