Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview
Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
A Jabłońska-Trypuć, M Matejczyk… - Journal of enzyme …, 2016 - Taylor & Francis
The main group of enzymes responsible for the collagen and other protein degradation in
extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main …
extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main …
Natural antioxidants: multiple mechanisms to protect skin from solar radiation
S Dunaway, R Odin, L Zhou, L Ji, Y Zhang… - Frontiers in …, 2018 - frontiersin.org
Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the
production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural …
production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural …
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …
S-nitrosylation: an emerging paradigm of redox signaling
Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …
Matrix metalloproteinases as novel biomarker s and potential therapeutic targets in human cancer
The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …
extracellular matrix remodeling proteases whose activity has been implicated in a number of …
Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis
S Dhup, R Kumar Dadhich… - Current …, 2012 - ingentaconnect.com
High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …
[HTML][HTML] The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas
S Koontongkaew - Journal of Cancer, 2013 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) is a complex tissue that contains tumor
cells and the surrounding stroma, which is populated by different types of mesenchymal …
cells and the surrounding stroma, which is populated by different types of mesenchymal …
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to
facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or …
facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or …
Progress in matrix metalloproteinase research
G Murphy, H Nagase - Molecular aspects of medicine, 2008 - Elsevier
Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation of
both cell–cell and cell–extracellular matrix interactions. They are involved in modifying …
both cell–cell and cell–extracellular matrix interactions. They are involved in modifying …