Haptoglobin: From hemoglobin scavenging to human health

A di Masi, G De Simone, C Ciaccio, S D'Orso… - Molecular Aspects of …, 2020 - Elsevier
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

Biomarkers for diagnosis of childhood tuberculosis: a systematic review

TO Togun, E MacLean, B Kampmann, M Pai - PloS one, 2018 - journals.plos.org
Introduction As studies of biomarkers of tuberculosis (TB) disease provide hope for a simple,
point-of-care test, we aimed to synthesize evidence on biomarkers for diagnosis of TB in …

Biomarkers of cell-mediated immunity to bovine tuberculosis

MV Palmer, TC Thacker, MM Rabideau… - Veterinary immunology …, 2020 - Elsevier
Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs),
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …

Heme oxygenase-1 regulation of matrix metalloproteinase-1 expression underlies distinct disease profiles in tuberculosis

BB Andrade, N Pavan Kumar, EP Amaral… - The Journal of …, 2015 - journals.aai.org
Pulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction
by matrix metalloproteinases (MMPs). The interplay between these distinct pathological …

Monocyte-to-lymphocyte ratio is associated with tuberculosis disease and declines with anti-TB treatment in HIV-infected children

RK Choudhary, KM Wall, I Njuguna… - JAIDS Journal of …, 2019 - journals.lww.com
Background: The blood monocyte-to-lymphocyte ratio (MLR) is associated with active
tuberculosis (TB) in adults but has not been evaluated as a TB diagnostic biomarker in HIV …

Epidemiology of extrapulmonary tuberculosis among pediatric inpatients in mainland China: a descriptive, multicenter study

P Chu, Y Chang, X Zhang, S Han, Y Jin… - Emerging microbes & …, 2022 - Taylor & Francis
Pediatric tuberculosis (TB) is a serious infectious disease that affects many children
worldwide and is more likely to be extrapulmonary than adult TB. However, the clinical and …

Matrix metalloproteinases in pulmonary and central nervous system tuberculosis—a review

UK Rohlwink, NF Walker, AA Ordonez, YJ Li… - International journal of …, 2019 - mdpi.com
Tuberculosis (TB) remains the single biggest infectious cause of death globally, claiming
almost two million lives and causing disease in over 10 million individuals annually. Matrix …

Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection

A Maji, R Misra, A Kumar Mondal, D Kumar, D Bajaj… - Scientific reports, 2015 - nature.com
Extrapulmonary manifestations constitute 15 to 20% of tuberculosis cases, with lymph node
tuberculosis (LNTB) as the most common form of infection. However, diagnosis and …

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

N Rockwood, DL Costa, EP Amaral… - Frontiers in …, 2017 - frontiersin.org
The antioxidant enzyme heme oxygenase-1 (HO-1) is implicated in the pathogenesis of
tuberculosis (TB) and has been proposed as a biomarker of active disease. Nevertheless …

[HTML][HTML] Role of cytokines and other factors involved in the Mycobacterium tuberculosis infection

TB Romero-Adrian, J Leal-Montiel… - World Journal of …, 2015 - wjgnet.com
Mycobacterium tuberculosis (Mtb) is a pathogen that is widely distributed geographically
and continues to be a major threat to world health. Bacterial virulence factors, nutritional …