This paper synthesizes recent progress toward understanding the integrated control systems
and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus …

T cells are known to migrate to B‐cell‐enriched follicles and germinal centers within
secondary lymphoid organs to provide help to B cells. Cognate T: B interactions that take …

A major goal of systems biology is the development of models that accurately predict
responses to perturbation. Constructing such models requires the collection of dense …

Objective To examine immunization responses in patients with rheumatoid arthritis (RA)
treated with rituximab and to investigate the effects of rituximab‐induced CD20+ B cell …

The bone marrow constitutes a favorable environment for long-lived antibody-secreting
plasma cells, providing blood-circulating antibody. Plasma cells are also present in mucosa …

Lysosomal storage diseases are characterized by deficiencies in lysosomal enzymes,
allowing accumulation of target substrate in cells and eventually causing cell death. Enzyme …

Abstract Objective Anti‐CD20–mediated B cell depletion with rituximab is a new and
effective therapy for rheumatoid arthritis (RA). Although B cells in peripheral blood (PB) are …

Depletion of B lymphocytes using the anti‐CD20 monoclonal antibody rituximab has wide‐
spread use in the treatment of patients with autoimmune disorders. As haematopoietic …

Controversy has arisen about the nature of circulating human CD20+ CD27+ CD43+ CD70−
CD69− B cells. Although originally described as being the human counterpart of murine B-1 …

The prototypic autoimmune disease, SLE, is known to be associated with polyclonal B cell
hyperreactivity. Developing an understanding of the complex nature of human B cell …