The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing
pattern and is one of the most frequently performed behavioural activities in rodents. In this …

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of
neurological conditions, the underlying mechanisms of action have been elusive. Growing …

Background Deep brain stimulation (DBS) has been proposed as an alternative to ablative
neurosurgery for severe treatment-resistant Obsessive-Compulsive Disorder (OCD) …

Context Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder that affects
2% of the general population. Even when the best available treatments are applied …

Background Severe, refractory obsessive–compulsive disorder (OCD) is a disabling
condition. Stimulation of the subthalamic nucleus, a procedure that is already validated for …

Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network
function implicated in major depression. Because a prominent clinical feature of depression …

Psychiatric neurosurgery teams in the United States and Europe have studied deep brain
stimulation (DBS) of the ventral anterior limb of the internal capsule and adjacent ventral …

Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …