Visible-light-induced cascade reaction: a sustainable approach towards molecular complexity

S Ghosh, P Pyne, A Ghosh, S Choudhury… - Organic & Biomolecular …, 2023 - pubs.rsc.org
Photoredox catalysis has demonstrated rapid evolution in the field of synthetic organic
chemistry. On the other hand, the splendour of cascade reactions in providing complex …

[RhCp*Cl2]2-Catalyzed Indole Functionalization: Synthesis of Bioinspired Indole-Fused Polycycles

AN Singh Chauhan, G Mali, G Dua, P Samant… - ACS …, 2023 - ACS Publications
Polycyclic fused indoles are ubiquitous in natural products and pharmaceuticals due to their
immense structural diversity and biological inference, making them suitable for charting …

Catalytic Asymmetric Polycyclization of Tertiary Enamides with Silyl Enol Ethers: Total Synthesis of (−)-Cephalocyclidin A

QB Zhuang, JR Tian, K Lu, XM Zhang… - Journal of the …, 2023 - ACS Publications
A catalytic enantioselective polycyclization of tertiary enamides with terminal silyl enol ethers
has been developed by virtue of Cu (OTf) 2 catalysis with a novel spiropyrroline-derived …

Photochemical Intermolecular Cyclopropanation Reactions of Allylic Alcohols for the Synthesis of [3.1. 0]-Bicyclohexanes

C Pei, C Empel, RM Koenigs - Organic Letters, 2023 - ACS Publications
Cyclopropane-fused lactones are highly desirable in drug and natural products synthesis.
Herein, we report on a photochemical, chemoselective reaction of aryldiazoacetates with …

Dipole‐Transmissive 1, 3‐Dipolar Cycloadditions for the Rapid Construction of Polycyclic N‐Heterocycles: Synthetic and Mechanistic Investigations

JS Henneveld, F Shiri, A Ariafard… - … A European Journal, 2023 - Wiley Online Library
The investigation of distinctive dipole‐transmissive dipolar cycloaddition (DTDC)
methodology and the formalisation of this concept is reported. A DTDC procedure was able …

Mn‐Mediated Radical Cascade Cyclization of 1,6‐Enynes with Arylboronic Acids to Access Dihydrobenzo[b]fluorenones

C Raji Reddy, R Chandrakant Kajare… - Advanced Synthesis & …, 2022 - Wiley Online Library
Herein, we report the synthesis of functionalized dihydro‐benzo [b] fluorenones through a
manganese‐mediated cascade radical cyclization of β‐alkynyl propenones [1, 6‐enynes] …

Substitution controlled aryne insertion: synthesis of diarylmethane/chromones

JR Dhanaji, P Samatha, S Raju, PS Mainkar… - Chemical …, 2023 - pubs.rsc.org
Aryne insertion reaction with 2-aroyl malonates/cyanoesters lead to the formation of
diarylmethane or chromones depending on the substitution on the aryne ring. The presence …

Recent Advances in [3+ 2]-Cycloaddition-Enabled Cascade Reactions: Application to Synthesize Complex Organic Frameworks

S Shivam, KA Chavan, ANS Chauhan, RD Erande - Synlett, 2023 - thieme-connect.com
Many natural products and biologically important complex organic scaffolds have
convoluted structures around their core skeleton. Interestingly, with just changing the …

Catalyst-Controlled Inter-and Intramolecular Cascade [4+ 2] Annulations via Benzopyrylium Intermediates

T Koshikawa, J Nogami, Y Nagashima, K Tanaka - ACS Catalysis, 2022 - ACS Publications
We report two types of catalyst-controlled inter-and intramolecular cascade [4+ 2]
annulations between diyne-carbonyls and alkenes, Pt (II)-catalyzed annulation with two …

Total Synthesis of Strigolactones via Palladium-Catalyzed Cascade Carbonylative Carbocyclization of Enallenes

B Yang, P Federmann, V Warth, M Ren, X Mu… - Organic …, 2024 - ACS Publications
Here we report an efficient route for synthesizing strigolactones (SLs) and their derivatives.
Our method relies on a palladium-catalyzed oxidative carbonylation/carbocyclization …