Suicide is a serious and growing public health concern yet randomized controlled trials
(RCTs) that inform pharmacologic treatment remain limited. We emphasize the overall need …

Suicidal ideation (SI) is understudied in obsessive-compulsive disorder (OCD).
Nonetheless, evidence suggests increased risk for SI in individuals with OCD compared to …

This article updates a 2006 review of empirical data concerning whether clinicians can
predict whether patients will die by suicide, or whether fatality can be prevented. Based on …

Recently, low-dose ketamine has been proposed as a rapid-acting treatment option for
suicidality. The majority of studies to date have utilised intravenous (IV) ketamine, however …

BACKGROUND: In Huntington's disease (HD) the risk of suicide is increased. Since
suicidality may precede suicide, this study investigates prevalence, clinical associations and …

Serotonin, or 5-hydroxytryptamine (5-HT), is a neurotransmitter with an integral physiological
role in the human body; it is involved in regulating various activities (eg, behavior, mood …

The major depressive disorder (MDD) working group of the Psychiatric Genomics
Consortium (PGC) has published a genome-wide association study (GWAS) for MDD in …

The influence of genetic background on sensitivity to drugs represents a topical problem of
personalized medicine. Here, we investigated the effect of chronic (20 mg/kg, 14 days, ip) …

Early life stress, including maternal separation, is among one of the main causes of anxiety
in adolescents. DNA methyltransferase 3A (Dnmt3a) is a key molecule that regulates DNA …

Depression is a highly prevalent and seriously impairing disorder. Evidence suggests that
music therapy can decrease depression, though the music therapy that is offered is often not …