Chapter summary Complement is implicated in the pathogenesis of systemic lupus
erythematosus (SLE) in several ways and may act as both friend and foe. Homozygous …

Complement deficient cases reported in the second half of the last century have been of
great help in defining the role of complement in host defence. Surveys of the deficient …

A major function of the immune system is to protect the host from microbial infections. The
complement system plays important roles in both the innate and the adaptive immune …

The complement system is a major, multifunctional part of innate immunity and serves as a
bridge between the innate and adaptive immune systems. It consists of more than 30 distinct …

SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience SIR, We
present the case of a 24-year-old female of Pakistani origin with an SLE-like illness …

The pathophysiology of systemic lupus erythematosus (SLE) has been intensely studied but
remains incompletely defined. Currently, multiple mechanisms are known to contribute to the …

The complement system plays a crucial role in host defense, homeostasis, and tissue
regeneration and bridges the innate and the adaptive immune systems. Although the …

Deficiencies in the classical pathway of complement activation have some common features
but show also great differences. Deficiencies of each of the components (C1q, C1s, C1r, C4 …

Psoriasis is a genetically determined hyperproliferative skin disease characterized by
increased cell proliferation, glycogen accumulation and incomplete differentiation in the …

Systemic autoinflammatory diseases (SAIDs) are disorders of innate immunity, which are
characterized by unprovoked recurrent flares of systemic inflammation often characterized …