Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

We performed an extensive immunogenomic analysis of more than 10,000 tumors
comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer …

We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Squamous cell carcinomas (SCCs) are one of the most frequent forms of human
malignancy, but, other than TP53 mutations, few causative somatic aberrations have been …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

Cellular decisions of self-renewal or differentiation arise from integration and reciprocal
titration of numerous regulatory networks. Notch and Wnt/β-catenin signalling often intersect …

A role for the beta genus HPVs in keratinocyte carcinoma (KC) remains to be established. In
this article we examine the potential role of the beta HPVs in cancer revealed by the …

The Hippo pathway is a crucial signaling mechanism that inhibits the growth of cells and
organs during development and in disease. When the Hippo pathway is activated, YAP/TAZ …