Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …

Bioinformatics pipelines are essential in the analysis of genomic and transcriptomic data
generated by next-generation sequencing (NGS). Recent guidelines emphasize the need …

In comparative high-throughput sequencing assays, a fundamental task is the analysis of
count data, such as read counts per gene in RNA-seq, for evidence of systematic changes …

RNA sequencing (RNA-seq) has been rapidly adopted for the profiling of transcriptomes in
many areas of biology, including studies into gene regulation, development and disease. Of …

Abstract RNA-sequencing (RNA-seq) has rapidly become a popular tool to characterize
transcriptomes. A fundamental research problem in many RNA-seq studies is the …

Background Intestinal macrophages are key immune cells in the maintenance of intestinal
immune homeostasis and have a role in the pathogenesis of inflammatory bowel disease …

Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals.
The degradation of TNF-α mRNA is critical for restricting TNF-α synthesis and involves a …

Processing raw reads of RNA-sequencing (RNA-seq) data, no matter public or newly
sequenced data, involves a lot of specialized tools and technical configurations that are …

RNA-Seq has become a potent and widely used method to qualitatively and quantitatively
study transcriptomes. To draw biological conclusions based on RNA-Seq data, several …

Purpose To perform a radiogenomic analysis of women with breast cancer to study the
multiscale relationships among quantitative computer vision–extracted dynamic contrast …