Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly
expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at …

Stroke is the second leading cause of death and the third leading cause of disability
globally. Edema is a hallmark of stroke resulting from dysregulation of water homeostasis in …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

Fluid transport at the nanoscale is ubiquitous in nature. However, rigorous study of fluid flow
and structure in artificial nanopores only emerged relatively recently. Termed nanofluidics …

Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …

Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …