Our understanding of bacterial pathogenesis is dominated by the cell biology of the host–
pathogen interaction. However, the majority of metabolites that are used in prokaryotic and …

Abstract l-asparaginase (EC 3.5. 1.1) is an important enzyme that has been purified and
characterized for over decades to study and evaluate its anti-carcinogenic activity against …

Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …

We constructed two collections of targeted single gene deletion (SGD) mutants and two
collections of targeted multi-gene deletion (MGD) mutants in Salmonella enterica sv …

Pathogens have evolved clever strategies to evade and in some cases exploit the attacks of
an activated immune system. Salmonella enterica is one such pathogen, exploiting multiple …

During the last decade Campylobacter jejuni has been recognized as the leading cause of
bacterial gastroenteritis worldwide. This facultative intracellular pathogen is a member of the …

The interaction between host and pathogen decidedly shapes the outcome of an infection,
thus understanding this interaction is critical to the treatment of a pathogen-induced …

Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M.
tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome, whose pH …

L-asparaginase is a vital enzyme of medical importance, and renowned as a
chemotherapeutic agent. The relevance of this enzyme is not only limited as an anti-cancer …

Microbial infection triggers assembly of inflammasome complexes that promote caspase-1–
dependent antimicrobial responses. Inflammasome assembly is mediated by members of …