Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can
occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic …

Mammalian palatogenesis is a highly regulated morphogenetic process during which the
embryonic primary and secondary palatal shelves develop as outgrowths from the medial …

The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …

Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

Cleft lip and/or cleft palate (CL/P) collectively are well known as being amongst the most
common birth defects but we still have difficulty explaining why the majority of cases occur …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Palatogenesis involves the initiation, growth, morphogenesis, and fusion of the primary and
secondary palatal shelves from initially separate facial prominences during embryogenesis …

Development of the mammalian secondary palate involves highly dynamic morphogenetic
processes, including outgrowth of palatal shelves from the oral side of the embryonic …

Human palatal clefting is debilitating and difficult to rectify surgically. Animal models
enhance our understanding of palatogenesis and are essential in strategies designed to …