Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Abstract The American Diabetes Association and the European Association for the Study of
Diabetes convened a panel to update the prior position statements, published in 2012 and …

This systematic review investigated whether the insulin sensitiser metformin has a
geroprotective effect in humans. Pubmed and Embase were searched along with databases …

The present study investigated the protective effect of hesperidin on carbohydrate
metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered …

Guidelines RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2
Diabetes Mellitus 2020Table. No title available.

This book builds on and is a sequel to our book Targeted Learning: Causal Inference for
Observational and Experimental Studies (2011). Since the publication of this first book on …

Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac) …

Summary The National Institute on Aging Interventions Testing Program (ITP) evaluates
agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each …

Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …