The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

Ischemic insults on neurons trigger excessive, pathological glutamate release that causes
Ca 2+ overload resulting in neuronal cell death (excitotoxicity). The Ca 2+/calmodulin (CaM) …

In this study, we investigated the effects and mechanism of quercetin preconditioning on anti-
myocardial ischemia reperfusion (IR) injuries in vivo. Meanwhile, their potential anti …

[EN] The reduced lifespan of cryopreserved spermatozoa in the mare reproductive tract has
been attributed to both capacitative and apoptotic changes. However, there is a lack of …

Aims Doxorubicin is widely used against cancer; however, it can produce heart failure (HF).
Among other hallmarks, oxidative stress is a major contributor to HF pathophysiology. The …

Key points Spontaneous sarcoplasmic reticulum (SR) Ca2+ release events increased in
fructose‐rich diet mouse (FRD) myocytes vs. control diet (CD) mice, in the absence of …

Background—Digitalis-induced Na+ accumulation results in an increase in Ca2+ i via the
Na+/Ca2+ exchanger, leading to enhanced sarcoplasmic reticulum (SR) Ca2+ load …

In adapting to disease and loss of tissue, the heart shows great phenotypic plasticity that
involves changes to its structure, composition and electrophysiology. Together with parallel …

Background To determine whether photobiomodulation (PBM) rescued the disruption of
Na+/Ca 2+ homeostasis and mitochondrial membrane potential by ouabain; the Na, K …

In different pathological situations, cardiac cells undergo hyperosmotic stress and cell
shrinkage. This change in cellular volume has been associated with contractile dysfunction …