Abstract The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial
growth factor domain-containing protein] family consists of three proteins in vertebrates …

Homeostatic signaling systems are fundamental forms of biological regulation that maintain
stable functionality in a changing environment. In the nervous system, synapses are crucial …

Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release
following diminished postsynaptic glutamate receptor (GluR) functionality to maintain …

In developing and mature nervous systems, diverse neuronal subtypes innervate common
targets to establish, maintain, and modify neural circuit function. A major challenge towards …

Robust neural information transfer relies on a delicate molecular nano-architecture of
chemical synapses. Neurotransmitter release is controlled by a specific arrangement of …

The Drosophila melanogaster neuromuscular junction (NMJ) is a superb system for studying
synapse function. Beyond that, the NMJ is also great for studying forms of synaptic plasticity …

The vertebrates' scaffold proteins of the Dlg-MAGUK family are involved in the recruitment,
clustering, and anchoring of glutamate receptors to the postsynaptic density, particularly the …

Nonlinear feedback controllers are ubiquitous features of biological systems at different
scales. A key motif arising in these systems is a sequestration-based feedback. As a …

Homeostatic plasticity represents a set of compensatory mechanisms that are engaged
following a perturbation to some feature of neuronal or network function. Homeostatic …

Synapses are endowed with the flexibility to change through experience, but must be
sufficiently stable to last a lifetime. This tension is illustrated at the Drosophila …