As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …

Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …

Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …

Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2,
occurs at tens of thousands to millions of sites across mammalian transcriptomes. A-to-I …

Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in
which severe inflammation occurs in the brain due to innate immune activation. Here, we …