Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Conspectus DNA-encoded library technology (DELT) is a new screening modality that
allows efficient, cost-effective, and rapid identification of small molecules with potential …

The past decade has witnessed the emergence of N-(acyloxy) phthalimides (NHPI esters)
and its derivatives at the forefront of synthetic methods facilitating the construction of diverse …

Exploiting nature's catalysts for non-natural transformations that are inaccessible to
chemocatalysis is highly desirable but challenging. On the one hand, the widespread …

This review illustrates pioneering work and recent advancements on the use of pro-aromatic
compounds as carbon-and heteroatom-radical precursors. Pro-aromatic systems such as 1 …

DNA-encoded libraries have proven their tremendous value in the identification of new lead
compounds for drug discovery. To access libraries in new chemical space, many methods …

DNA-encoded library (DEL) technology features a time-and cost-effective interrogation
format for the discovery of therapeutic candidates in the pharmaceutical industry. To develop …

The synthesis of quaternary carbons often requires numerous steps and complex conditions
or harsh reagents that act on heavily engineered substrates. This is largely a consequence …

Alcohols are among the most widely occurring functional groups found in naturally
abundant, biologically relevant organic compounds, which in many cases are considered …

The potential of electron donor–acceptor (EDA) complex photochemistry has recently been
recognized in visible-light-induced photocatalyst-free radical reactions. The design of …