Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

Chow LT, Broker TR, Steinberg BM. The natural history of human papillomavirus infections
of the mucosal epithelia. APMIS 2010; 118: 422–449. Human papillomaviruses (HPVs) …

Collagen-induced arthritis (CIA) is an established mouse model of disease with hallmarks of
clinical rheumatoid arthritis. Histone/protein deacetylase inhibitors (HDACi) are known to …

The p53 protein is one of the most important tumor suppressor proteins. Normally, the p53
protein is in a latent state. However, when its activity is required, eg upon DNA damage …

GCN5, conserved from yeast to humans, and the vertebrate specific PCAF, are lysine
acetyltransferase enzymes found in large protein complexes. Both enzymes have well …

In Arabidopsis, CBF transcription factors bind to and activate certain cold-regulated (COR)
gene promoters during cold acclimation. Consistent with the prevailing model that histone …

The ability of p53 to act as a transcription factor is critical for its function as a tumor
suppressor. Ankyrin repeat domain 11, ANKRD11 (also known as ANR11 or ANCO1), was …

Mutations in human nonsense-mediated mRNA decay (NMD) factors are enriched in
neurodevelopmental disorders. We show that deletion of key NMD factor Upf2 in mouse …

Most agents that damage DNA act through posttranslational modifications of p53 and
activate its downstream targets. However, whether cellular responses to nucleoside …

Ada3 protein is an essential component of histone acetyl transferase containing coactivator
complexes conserved from yeast to human. We show here that germline deletion of Ada3 in …