Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain …

R Colón Ortiz, S Knerler, LB Fridman… - Fluids and Barriers of …, 2024 - Springer
Background Appropriate interactions between antiretroviral therapies (ART) and drug
transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure …

Neuro-immune deconvolution analysis of OAS3 as a transcriptomic central node in HIV-associated neurocognitive disorders

C Sanfilippo, P Castrogiovanni, M Vinciguerra… - Journal of the …, 2023 - Elsevier
Neurological complications of AIDS (NeuroAIDS) include primary HIV-associated
neurocognitive disorder (HAND). OAS3 is an enzyme belonging to the 2′, 5 …

ABCG2 polymorphisms and susceptibility to ARV‐associated hepatotoxicity

HO Singh, K Dhotre, Shyamveer… - … Genetics & Genomic …, 2024 - Wiley Online Library
Abstract Background The ABCG2 421C/A polymorphism contributes significantly to the
distribution and absorption of antiretroviral (ARV) regimens and is associated with the …

[HTML][HTML] Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at …

LB Fridman, S Knerler, AS Price, RC Ortiz, A Mercado… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background Appropriate interactions between antiretroviral therapies (ART) and drug
transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure …