Over the past decade, methods for predicting three-dimensional (3-D) chromosome and
genome structures have proliferated. This has been primarily due to the development of high …

Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …

Motivation The spatial genome organization of a eukaryotic cell is important for its function.
The development of single-cell technologies for probing the 3D genome conformation …

Understanding the packing of long DNA strands into chromatin is one of the ultimate
challenges in genomic research. An intrinsic part of this complex problem is studying the …

Motivation The 3D structure of chromatin in the nucleus is important for gene expression and
regulation. Chromosome conformation capture techniques, such as Hi-C, generate large …

Advances in the study of chromosome conformation capture technologies, such as Hi-C
technique-capable of capturing chromosomal interactions in a genome-wide scale-have led …

Background Chromosome is one of the most fundamental part of cell biology where DNA
holds the hierarchical information. DNA compacts its size by forming loops, and these …

Over the past two decades, scientists have increasingly realized the importance of the three-
dimensional (3D) genome organization in regulating cellular activity. Hi-C and related …

The functions of eukaryotic chromosomes and their spatial architecture in the nucleus are
reciprocally dependent. Hi-C experiments are routinely used to study chromosome 3D …

Motivation High throughput chromosome conformation capture (Hi-C) contact matrices are
used to predict 3D chromatin structures in eukaryotic cells. High-resolution Hi-C data are …