The success of targeted therapies and immunotherapies has created optimism that cancers
may be curable. However, not all patients respond, drug resistance is common and many …

The transforming growth factor (TGF)-β family is a group of structurally related,
multifunctional growth factors, or ligands that are crucially involved in the development …

Thrombocytopenia is a major complication in a subset of patients with multiple myeloma
(MM). However, little is known about its development and significance during MM. Here, we …

Multiple myeloma is rarely curable and its interactions with the bone marrow
microenvironment are evident. However, separating cause from effect remains a challenge …

Osteolytic bone disease is a hallmark of multiple myeloma (MM). A significant fraction (~
20%) of MM patients do not develop osteolytic lesions (OLs). The molecular basis for the …

Simple Summary Multiple myeloma is a cancer of immunoglobulin-secreting cells that
accumulate in the bone marrow. Mesenchymal stromal cells are important components of …

The hallmark of multiple myeloma (MM) is a clonal plasma cell infiltration in the bone
marrow accompanied by myelosuppression and osteolysis. Premalignant stages such as …

Metastatic tumors present great challenges in diagnosis and treatment. Herein, a proof-of-
concept theranostic nanoplatform composed of an Au nanoparticle core and a double-shell …

Osteoarthritis (OA) is a highly prevalent and debilitating joint disorder that characterized by
progressive destruction of articular cartilage. There is no effective disease-modifying therapy …

Natural killer (NK) cells represent a subset of CD3-CD7+ CD56+/dim lymphocytes with
cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall …