Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to
an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with …

In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well
studied at high glucose levels, comparatively little is known about its origin under basal …

Using the FitzHugh-Nagumo equations to represent the oscillatory electrical behavior of β-
cells, we develop a coupled oscillator network model with cubic lattice topology, showing …

The intestine has garnered attention as a target organ for developing new therapies for
impaired glucose tolerance. The intestine, which produces incretin hormones, is the central …

Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In
pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by …

Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been
attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show …

Background: The rs7903146 variant in the TCF7L2 gene is associated with defects in
postprandial insulin and glucagon secretion and increased risk of type 2 diabetes. However …

Objective Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are
characterized by insulin resistance. This has led to the suggestion that changes in insulin …

OBJECTIVE We aimed to test whether type 2 diabetes (T2D)–associated TCF7L2 genetic
variants affect insulin sensitivity or secretion in autoantibody-positive relatives at risk for type …

The diabetes types and its complications have varying developmental and metabolic
pathways. There is an interplay of nongenetic and genetic components in pathogenesis of …