Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the
substantia nigra is a hallmark of Parkinson's disease. Yet, whether this change contributes to …

Although serum from patients with Parkinson's disease contains elevated levels of
numerous pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of
dopaminergic neurons in the substantia nigra pars compacta (SN c). Alpha‐synuclein …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

How do neurons match generation of adenosine triphosphate by mitochondria to the
bioenergetic demands of regenerative activity? Although the subject of speculation, this …

Abnormal aggregation of α-synuclein is thought to be one of core pathogenic factors in PD.
Ca2+ can bind to the C-terminus of α-synuclein, regulate the secretion of α-synuclein, and …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …