Regulation of gene transcription is vitally important for the maintenance of normal cellular
homeostasis. Failure to correctly regulate gene expression, or to deal with problems that …

Ubiquitin (Ub) is a 76-amino acid protein that is ubiquitously distributed and highly
conserved throughout eukaryotic organisms. Whereas the extreme C-terminal four amino …

Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …

Xeroderma pigmentosum (XP) is a heritable human disorder characterized by defects in
nucleotide excision repair (NER) and the development of skin cancer. Cells from XP group E …

Nucleosomal organization in and around genes may contribute substantially to
transcriptional regulation. The contribution of histone modifications to genome-wide …

The mechanism by which ubiquitination of histone H2B (H2Bub1) regulates H3-K4 and-K79
methylation and the histone H2A-H2B chaperone Spt16-mediated nucleosome dynamics …

Despite the fact that histone H2A ubiquitination affects about 10–15% of this histone in most
eukaryotic cells, histone ubiquitination is among one of the less‐well‐characterized post …

Regulation of Set1-COMPASS-mediated H3K4 methylation and Dot1-mediated H3K79
methylation by H2BK123 ubiquitination (H2Bub1) is an evolutionarily conserved trans …

Post-translational modifications (PTMs) of histones are an essential feature in the dynamic
regulation of chromatin. One of these modifications, ubiquitylation, has been speculated to …

DNA in nucleosomes has restricted nucleosome dynamics and is refractory to DNA-
templated processes. Histone post-translational modifications play important roles in …