Olfactory system and energy metabolism: a two-way street

P Jovanovic, CE Riera - Trends in Endocrinology & Metabolism, 2022 - cell.com
Olfactory perception guides daily decisions regarding food consumption, social interactions,
and predator avoidance in all mammalian species. Volatile inputs, comprising odorants and …

A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus

P Jovanovic, AH Pool, N Morones, Y Wang… - Nature …, 2023 - nature.com
Olfactory cues are vital for prey animals like rodents to perceive and evade predators. Stress-
induced hyperthermia, via brown adipose tissue (BAT) thermogenesis, boosts physical …

Olfactory modulation of stress-response neural circuits

MG Shin, Y Bae, R Afzal, K Kondoh… - Experimental & Molecular …, 2023 - nature.com
Stress responses, which are crucial for survival, are evolutionally conserved throughout the
animal kingdom. The most common endocrine axis among stress responses is that triggered …

Paraventricular thalamic MC3R circuits link energy homeostasis with anxiety-related behavior

D Cho, K O'Berry, IC Possa-Paranhos… - Journal of …, 2023 - Soc Neuroscience
The hypothalamic melanocortin system is critically involved in sensing stored energy and
communicating this information throughout the brain, including to brain regions controlling …

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

S Ramírez, R Haddad-Tovolli, M Radosevic, M Toledo… - Cell metabolism, 2022 - cell.com
Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the
hypothalamus is implicated in energy balance control and memory disorders, we …

Stress integration by an ascending adrenergic-melanocortin circuit

C Laule, N Sayar-Atasoy, I Aklan, H Kim… - …, 2024 - nature.com
Stress is thought to be an important contributing factor for eating disorders; however, neural
substrates underlying the complex relationship between stress and appetite are not fully …

Unveiling Hypothalamic Molecular Signatures via Retrograde Viral Tracing and Single-Cell Transcriptomics

M Junaid, HK Choe, K Kondoh, EJ Lee, SB Lim - Scientific Data, 2023 - nature.com
Despite the importance of hypothalamic neurocircuits in regulating homeostatic and survival-
related behaviors, our understanding of the intrinsic molecular identities of neural …

Odor blocking of stress hormone responses

EJ Lee, LR Saraiva, NK Hanchate, X Ye, G Asher… - Scientific Reports, 2022 - nature.com
Scents have been employed for millennia to allay stress, but whether or how they might do
so is largely unknown. Fear and stress induce increases in blood stress hormones …

Proteostasis and resilience: On the interphase between individual's and intracellular stress

ML Díaz-Hung, C Hetz - Trends in Endocrinology & Metabolism, 2022 - cell.com
A long proportion of the population is resilient to the negative consequences of stress.
Glucocorticoids resulting from endocrine responses to stress are essential adaptive …

Neuronal heterogeneity in the paraventricular nucleus of the hypothalamus as revealed by single-cell RNA-seq

RA Romanov, T Harkany - Current Opinion in Endocrine and Metabolic …, 2022 - Elsevier
The evoked release of corticotropin-releasing hormone (CRH) from nerve endings at the
median eminence is the single most powerful endocrine trigger for the hormonal cascade …