Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Computationally driven engineering of proteins aims to allow them to withstand an extended
range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the …

The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …

Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in
autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively …

Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and
has autoantigenic properties in multiple sclerosis (MS). Its intracellular interaction network is …

Immunoproteasome is a variant of proteasome with structural differences in 20S subunits
optimizing them for the production of antigenic peptides with higher binding affinity to major …

This work explored the molecular origin of substrate translocation by the AAA+ motor of the
26S proteasome. This exploration was performed by combining different simulation …

PA28γ is a nuclear activator of the 20S proteasome that, unlike the 19S regulatory particle,
stimulates hydrolysis of several substrates in an ATP-and ubiquitin-independent manner …