The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …

Nearly all organisms are hosts to multiple viruses that collectively appear to be the most
abundant biological entities in the biosphere. With recent advances in metagenomics and …

DEV is an obligatory lytic Pseudomonas phage of the N4-like genus, recently reclassified as
Schitoviridae. The DEV genome encodes 91 ORFs, including a 3398 amino acid virion …

To kill bacteria, bacteriophages (phages) must first bind to a receptor, triggering the release
of the phage DNA into the bacterial cell. Many bacteria secrete polysaccharides that had …

In 1952, Hershey and Chase used bacteriophage T2 genome delivery inside Escherichia
coli to demonstrate that DNA, not protein, is the genetic material. Over 70 years later, our …

Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …

Phages have been approved for use in the food industry to control bacterial contamination in
some countries. However, their broader adoption is hindered by some limitations. For …

In a survey of a waterway on Wurundjeri land, two sub-populations of the bacteriophage
Merri-merri-uth nyilam marra-natj (phage MMNM) were isolated on a permissive host …

Bacterial pathogens in water, food, and the environment are spreading diseases around the
world. According to a World Health Organization (WHO) report, waterborne pathogens pose …

A contractile sheath and rigid tube assembly is a widespread apparatus used by
bacteriophages, tailocins, and the bacterial type VI secretion system to penetrate cell …