Animal models play a crucial role in fundamental and medical research. Progress in the
fields of drug discovery, regenerative medicine and cancer research among others are …

The developing limb is a major model for pattern formation in vertebrate embryos. Many of
the seminal discoveries of the mechanisms involved in patterning have been made using …

Synchrotron radiation micro-computed tomography (SRµCT) based virtual histology, in
combination with dedicated ex vivo staining protocols and/or phase contrast, is an emerging …

Driven by a global trend of applying replace-reduce-refine or 3Rs' guidance for experimental
animals in life sciences, chick embryo and particularly allantois with its chorioallantoic …

Animals have evolved limb proportions adapted to different environments, but it is not yet
clear to what extent these proportions are directly influenced by the environment during …

Chick embryos are an important animal model for biomedical studies. The visualization of
chick embryos, however, is limited mostly to postmortem sectional imaging methods. In this …

High-resolution Magnetic Resonance Imaging (MRI) has been the primary modality for
obtaining 3D cross-sectional anatomical information in animals for soft tissue, particularly …

The Hen's Egg Test Chorioallantoic Membrane (HET-CAM) of fertilized chick eggs
represents a unique model for biomedical research. With its steadily increasing use, non …

Embryonic development is a remarkably complex and rapidly evolving morphogenetic
process. Although many of the early patterning events have been well described …

Rapid three‐dimensional imaging of embryos to better understand the complex process of
morphogenesis has been challenging. Recently introduced iodine staining protocols (I 2 KI …