Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis
pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP). GGPP …

Male infertility has affected many families around the world. However, due to the mechanism
underlying male reproductive system dysfunction are not completely elucidated, the use of …

Blood-testis barrier (BTB) damage promotes spermatogenesis dysfunction, which is a critical
cause of male infertility. Dyslipidemia has been correlated with male infertility, but the major …

Microcystin-leucine arginine (MC-LR), an emerging water pollutant, produced by
cyanobacteria, has an acute testicular toxicity. However, little is known about the chronic …

Spermatogenic dysfunction is one of the major secondary complications of male diabetes.
Salidroside (SAL) is the important active ingredients isolated from Herba Cistanche, which …

Spermatogenesis is a complex and elaborate differentiation process and is critical for male
fertility. The hypothalamic-pituitary–gonadal axis serves as a significant neuroendocrine …

Zearalenone (ZEA) is an estrogen-like mycotoxin, which mainly led to reproductive toxicity.
The study aimed to investigate the molecular mechanism of ZEA-induced dysfunction of …

Humans are exposed to an ever-increasing number of environmental toxicants, some of
which have gradually been identified as major risk factors for male reproductive health, even …

Male factor infertility affects 50% of infertile couples worldwide; the most severe form, non-
obstructive azoospermia (NOA), affects 10–15% of infertile males. Treatment for individuals …

Background NOD-like receptor protein 3 (NLRP3) inflammasome activation has emerged as
a crucial contributor to sepsis-induced lung injury. Geranylgeranyl diphosphate synthase 1 …