Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Airway remodeling encompasses the structural alterations in asthmatic compared with
normal airways. Airway remodeling in asthmatic patients involves a wide array of …

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

To identify airway pathologic abnormalities selectively associated with severe asthma, we
examined 10 control subjects, 10 patients with intermittent asthma, 15 patients with mild-to …

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …

Eosinophil-derived TGF-β has been implicated in remodeling events in asthma. We
hypothesized that reduction of bronchial mucosal eosinophils with anti–IL-5 would reduce …

The mechanisms contributing to airway wall remodeling in asthma are under investigation to
identify appropriate therapeutic targets. Bronchial myofibroblasts would represent an …

Airway remodelling refers to the structural changes that occur in both large and small
airways relevant to miscellaneous diseases including asthma. In asthma, airway structural …