Molecular mechanisms of RNA targeting by Cas13-containing type VI CRISPR–Cas systems
MR O'Connell - Journal of molecular biology, 2019 - Elsevier
Prokaryotic adaptive immune systems use Clustered Regularly Interspaced Short
Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins for RNA-guided …
Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins for RNA-guided …
Predicting protein function from sequence and structure
While the number of sequenced genomes continues to grow, experimentally verified
functional annotation of whole genomes remains patchy. Structural genomics projects are …
functional annotation of whole genomes remains patchy. Structural genomics projects are …
PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
Motivation: PSORTb has remained the most precise bacterial protein subcellular localization
(SCL) predictor since it was first made available in 2003. However, the recall needs to be …
(SCL) predictor since it was first made available in 2003. However, the recall needs to be …
Gram-positive and Gram-negative protein subcellular localization by incorporating evolutionary-based descriptors into Chou׳ s general PseAAC
Protein subcellular localization is defined as predicting the functioning location of a given
protein in the cell. It is considered an important step towards protein function prediction and …
protein in the cell. It is considered an important step towards protein function prediction and …
Machine learning techniques for protein function prediction
R Bonetta, G Valentino - Proteins: Structure, Function, and …, 2020 - Wiley Online Library
Proteins play important roles in living organisms, and their function is directly linked with
their structure. Due to the growing gap between the number of proteins being discovered …
their structure. Due to the growing gap between the number of proteins being discovered …
Subcellular localization of marine bacterial alkaline phosphatases
Bacterial alkaline phosphatases (APases) are important enzymes in organophosphate
utilization in the ocean. The subcellular localization of APases has significant ecological …
utilization in the ocean. The subcellular localization of APases has significant ecological …
Horizontal gene transfer of the secretome drives the evolution of bacterial cooperation and virulence
Background Microbes engage in a remarkable array of cooperative behaviors, secreting
shared proteins that are essential for foraging, shelter, microbial warfare, and virulence …
shared proteins that are essential for foraging, shelter, microbial warfare, and virulence …
Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes
GL Winsor, T Van Rossum, R Lo, B Khaira… - Nucleic acids …, 2009 - academic.oup.com
Pseudomonas aeruginosa is a well-studied opportunistic pathogen that is particularly known
for its intrinsic antimicrobial resistance, diverse metabolic capacity, and its ability to cause …
for its intrinsic antimicrobial resistance, diverse metabolic capacity, and its ability to cause …
Plasmids do not consistently stabilize cooperation across bacteria but may promote broad pathogen host-range
Horizontal gene transfer via plasmids could favour cooperation in bacteria, because transfer
of a cooperative gene turns non-cooperative cheats into cooperators. This hypothesis has …
of a cooperative gene turns non-cooperative cheats into cooperators. This hypothesis has …
Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems
R Samudrala, F Heffron, JE McDermott - PLoS pathogens, 2009 - journals.plos.org
The type III secretion system is an essential component for virulence in many Gram-negative
bacteria. Though components of the secretion system apparatus are conserved, its …
bacteria. Though components of the secretion system apparatus are conserved, its …