Phagocytic microglia and macrophages in brain injury and repair
Aims Phagocytosis is the cellular digestion of extracellular particles, such as pathogens and
dying cells, and is a key element in the evolution of central nervous system (CNS) disorders …
dying cells, and is a key element in the evolution of central nervous system (CNS) disorders …
[HTML][HTML] Multivalent glycosystems for human lectins
M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …
pathological, which have attracted the interest of the scientific community working in the …
[HTML][HTML] Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues
Glycosylation is essential to brain development and function, but prior studies have often
been limited to a single analytical technique and excluded region-and sex-specific analyses …
been limited to a single analytical technique and excluded region-and sex-specific analyses …
[HTML][HTML] Neuroinflammation: a possible link between chronic vascular disorders and neurodegenerative diseases
Various age-related diseases involve systemic inflammation, ie a stereotyped series of acute
immune system responses, and aging itself is commonly associated with low-grade …
immune system responses, and aging itself is commonly associated with low-grade …
[HTML][HTML] Sialylation and galectin-3 in microglia-mediated neuroinflammation and neurodegeneration
M Puigdellívol, DH Allendorf, GC Brown - Frontiers in cellular …, 2020 - frontiersin.org
Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …
The genetic regulation of protein expression in cerebrospinal fluid
Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …
[HTML][HTML] Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Background Amongst risk alleles associated with late-onset Alzheimer's disease (AD), those
that converged on the regulation of microglia activity have emerged as central to disease …
that converged on the regulation of microglia activity have emerged as central to disease …
[HTML][HTML] Plasma dilution improves cognition and attenuates neuroinflammation in old mice
M Mehdipour, T Mehdipour, CM Skinner, N Wong… - Geroscience, 2021 - Springer
Our recent study has established that young blood factors are not causal, nor necessary, for
the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral …
the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral …
[HTML][HTML] Siglecs as therapeutic targets in cancer
Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …
[HTML][HTML] Sialometabolism in brain health and Alzheimer's disease
P Rawal, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are
mostly found as terminal residues in glycan structures of glycoconjugates including both …
mostly found as terminal residues in glycan structures of glycoconjugates including both …