Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic
and disease settings, such as inflammatory bowel disease (IBD), particularly in the context of …

Immune aging combines cellular defects in adaptive immunity with the activation of
pathways causing a low-inflammatory state. Here we examined the influence of age on the …

Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models
suggest that it can promote tumor growth. Here, we show that IL-9 signaling is associated …

Allergic diseases are a major global health issue. Interleukin (IL)-9-producing helper T (TH9)
cells promote allergic inflammation, yet TH9 cell effector functions are incompletely …

Abstract Background Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex,
mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig) …

Abstract Interleukin-9 (IL-9)-producing CD4+ T helper cells (Th9) have been implicated in
allergy/asthma and anti-tumor immunity, yet molecular insights on their differentiation from …

Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …

Background Hepatic ischemia-reperfusion injury (IRI) is considered as an effecting factor for
hepatocellular carcinoma (HCC) recurrence. Th17/Treg cells are a pair of essential …

Sex differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in
females, regulate sex differences in hepatic STAT5 activation linked to sex differences in …