Importance Clinicians, patients, and policy makers rely on published results from clinical
trials to help make evidence-informed decisions. To critically evaluate and use trial results …

Importance Complete information in a trial protocol regarding study outcomes is crucial for
obtaining regulatory approvals, ensuring standardized trial conduct, reducing research …

Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …

Background The Medical Research Council published the second edition of its framework in
2006 on developing and evaluating complex interventions. Since then, there have been …

Background: High intake of marine n-3 polyunsaturated fatty acids (PUFA) has been
associated with reduced risk of cardiovascular events; however, this has not been confirmed …

Randomised controlled trials remain the reference standard for healthcare research on
effects of interventions, and the need to report both benefits and harms is essential. The …

Background Since sequencing techniques have become less expensive, larger sample
sizes are applicable for microbiota studies. The aim of this study is to show how, and to what …

Results from clinical trials can be deemed trustworthy only if they are properly conducted
and their methods are fully reported. The SPIRIT and CONSORT checklists, which have …

Rationale: A recent randomized controlled trial showed that a peripheral perfusion–guided
resuscitation strategy was associated with lower mortality and less organ dysfunction when …

Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on
the impact of disease and treatment on patients' symptoms, function and quality of life. High …