Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

The excitotoxic hypothesis of neurodegeneration has stimulated much interest in the
possibility of using compounds that will block excitotoxic processes to treat neurologic …

Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis
(ALS). Here, through a combination of RNA-Seq and electrophysiological studies on …

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …

Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

TDP-43 dysfunction is common to 97% of amyotrophic lateral sclerosis (ALS) cases,
including those with mutations in C9orf72. To investigate how C9ORF72 mutations drive …

Unfortunately and despite all efforts, amyotrophic lateral sclerosis (ALS) remains an
incurable neurodegenerative disorder characterized by the progressive and selective death …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is characterized by
selective upper and lower motor neuron degeneration, the pathogenesis of which is …

Glutamate is an essential neurotransmitter regulating brain functions. Excitatory amino acid
transporter (EAAT)-2 is one of the major glutamate transporters primarily expressed in …

Excitotoxicity may play a role in certain disorders of the motor system thought to be caused
by environmentally acquired toxins, including lathyrism and domoic acid poisoning. Motor …