Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

The introduction of local anaesthesia some years after the first public demonstration of
general anaesthesia not surprisingly created less excitement and interest amongst both the …

Background QX-314 is a quaternary lidocaine derivative considered to be devoid of
clinically useful local anesthetic activity. However, several reports document that …

Background Amitriptyline is a tricyclic antidepressant drug used systemically for the
management of neuropathic pain. Antidepressants, as a class of drugs with direct neurologic …

This pocket-sized comprehensive classic, crammed with useful facts, is back in a fully-
updated 13th edition. Ideal for the practising anaesthetist or senior trainee, it covers a vast …

Background Increasing the duration of local anesthesia and/or creating greater differential
blockade (ie, selective block of pain-transmitting nerve fibers) has been attempted by …

Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation. Background
We investigated the effects of amitriptyline in the urinary tract smooth muscle and …

Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive
disorders. Recent studies further demonstrated that TCAs have potent sodium channel …

Background We recently found that peripheral administration of the quaternary lidocaine
derivative, QX-314, produces long-lasting sensory and motor blockade in animals. The goal …

Oral tricyclic antidepressants, widely used as adjuncts in the treatment of chronic pain, block
sodium channels in vitro and nerve conduction in vivo. However, toxicity of amitriptyline has …