The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Glucocorticoids are essential steroid hormones secreted from the adrenal gland in response
to stress. Since their discovery in the 1940s, glucocorticoids have been widely prescribed to …

In response to physiological and psychogenic stressors, the hypothalamic–pituitary–adrenal
(HPA) axis orchestrates the systemic release of glucocorticoids (GCs). By virtue of nearly …

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor
belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically …

Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent
interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes …

Glucocorticoids are essential for maintaining homeostasis and regulate a wide variety of
physiological processes. Therapeutically, synthetic glucocorticoids are widely prescribed for …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

Coronavirus disease 19 (COVID-19) is placing a major burden on healthcare, economy and
social systems worldwide owing to its fast spread and unacceptably high death toll. The …

The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate
the transcriptional functions of nuclear receptors and other transcription factors, and are the …