[HTML][HTML] Red blood cell storage lesion: causes and potential clinical consequences

T Yoshida, M Prudent, A D'Alessandro - Blood Transfusion, 2019 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Red blood cell metabolism in vivo and in vitro

A D'Alessandro, AT Anastasiadi, VL Tzounakas… - Metabolites, 2023 - mdpi.com
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data

Q Yang, Y Wang, Y Zhang, F Li, W Xia… - Nucleic acids …, 2020 - academic.oup.com
Biological processes (like microbial growth & physiological response) are usually dynamic
and require the monitoring of metabolic variation at different time-points. Moreover, there is …

[HTML][HTML] Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate …

A D'Alessandro, X Fu, T Kanias, JA Reisz… - …, 2020 - pmc.ncbi.nlm.nih.gov
Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …

Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes

T Nemkov, D Stephenson, EJ Earley, GR Keele, A Hay… - Cell Metabolism, 2024 - cell.com
Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …

Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III …

A D'Alessandro, R Culp‐Hill, JA Reisz… - …, 2019 - Wiley Online Library
BACKGROUND Biological and technical variability has been increasingly appreciated as a
key factor impacting red blood cell (RBC) storability and, potentially, transfusion outcomes …

Temperature enhanced succinate production concurrent with increased central metabolism turnover in the cyanobacterium Synechocystis sp. PCC 6803

T Hasunuma, M Matsuda, Y Kato, CJ Vavricka… - Metabolic …, 2018 - Elsevier
Succinate is a versatile petrochemical compound that can be produced by microorganisms,
often from carbohydrate based carbon sources. Phototrophic cyanobacteria including …

Hypoxic storage of red blood cells improves metabolism and post‐transfusion recovery

A DʼAlessandro, T Yoshida, S Nestheide… - …, 2020 - Wiley Online Library
BACKGROUND Blood transfusion is a lifesaving intervention for millions of recipients
worldwide every year. Storing blood makes this possible but also promotes a series of …

[HTML][HTML] Model-driven insights into the effects of temperature on metabolism

P Wendering, Z Nikoloski - Biotechnology Advances, 2023 - Elsevier
Temperature affects cellular processes at different spatiotemporal scales, and identifying the
genetic and molecular mechanisms underlying temperature responses paves the way to …

VAMS-based blood capillary sampling for mass spectrometry-based human metabolomics studies

C Volani, C Malfertheiner, G Caprioli, S Fjelstrup… - Metabolites, 2023 - mdpi.com
Volumetric absorptive microsampling (VAMS) is a recently developed sample collection
method that enables single-drop blood collection in a minimally invasive manner. Blood …