The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …
a diverse spectrum of neurological complications during the acute and postacute stages …
Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
[HTML][HTML] Dysregulation of brain and choroid plexus cell types in severe COVID-19
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration
L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
L Zhang, A Richards, MI Barrasa… - Proceedings of the …, 2021 - National Acad Sciences
Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
RNA and recurrence of PCR-positive tests have been widely reported in patients after …
RNA and recurrence of PCR-positive tests have been widely reported in patients after …
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …
multiple organ systems including the central nervous system (CNS). Yet, there is no …
[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …
[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids
Summary Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
[HTML][HTML] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2
Y Gu, J Cao, X Zhang, H Gao, Y Wang, J Wang, J He… - Cell research, 2022 - nature.com
Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …