Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Gut microbiota has a fundamental role in the energy homeostasis of the host and is essential
for proper “education” of the immune system. Intestinal microbial communities are able to …

Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a
desensitizing therapy for IgE-mediated allergic diseases and represents a potentially …

The prevalence of allergic diseases has significantly increased in industrialized countries.
Allergen-specific immunotherapy (AIT) remains as the only curative treatment. The …

Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …

Transcription factor Foxp3 is critical for generating regulatory T cells (Treg cells).
Transforming growth factor-β (TGF-β) induces Foxp3 and suppressive Treg cells from naive …

Summary Forkhead Box P3 (Foxp3)-expressing regulatory T (Treg) cells are central to
maintaining self-tolerance and immune homeostasis. How Treg cell function and Foxp3 …

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the
accumulation of inflammatory cells; however, an eosinophil predominance is seen in white …