Myocardial infarction accelerates breast cancer via innate immune reprogramming
Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity or
surgery, alters cancer pathogenesis. Patients with cancer, particularly those with breast …
surgery, alters cancer pathogenesis. Patients with cancer, particularly those with breast …
Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity
JA Carozza, V Böhnert, KC Nguyen, G Skariah… - Nature cancer, 2020 - nature.com
Cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in
response to cytosolic double-stranded DNA and activates the innate immune STING …
response to cytosolic double-stranded DNA and activates the innate immune STING …
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance
INTRODUCTION A central tenet of the clonal selection theory (CST), the current cornerstone
of adaptive immunity, states that naïve T cells are selected on the basis of specificity to …
of adaptive immunity, states that naïve T cells are selected on the basis of specificity to …
Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke
Monocyte-derived and tissue-resident macrophages are ontogenetically distinct
components of the innate immune system. Assessment of their respective functions in …
components of the innate immune system. Assessment of their respective functions in …
Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex-and age-related functional regulation
RJ Lu, S Taylor, K Contrepois, M Kim, JI Bravo… - Nature aging, 2021 - nature.com
Neutrophils are the most abundant human white blood cell and constitute a first line of
defense in the innate immune response. Neutrophils are short-lived cells and thus the …
defense in the innate immune response. Neutrophils are short-lived cells and thus the …
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation
Imidazoquinolines (IMDs), such as resiquimod (R848), are of great interest as potential
cancer immunotherapies because of their ability to activate Toll-like receptor 7 (TLR7) …
cancer immunotherapies because of their ability to activate Toll-like receptor 7 (TLR7) …
Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice
Diabetic foot ulceration is a devastating diabetic complication with unmet needs. We
explored the efficacy of calcium-crosslinked alginate dressings in topically delivering …
explored the efficacy of calcium-crosslinked alginate dressings in topically delivering …
Boosting the biogenesis and secretion of mesenchymal stem cell-derived exosomes
A limitation of using exosomes to their fullest potential is their limited secretion from cells, a
major bottleneck to efficient exosome production and application. This is especially true for …
major bottleneck to efficient exosome production and application. This is especially true for …
Fasting-activated ventrolateral medulla neurons regulate T cell homing and suppress autoimmune disease in mice
L Wang, M Cheng, Y Wang, J Chen, F Xie… - Nature …, 2024 - nature.com
Dietary fasting markedly influences the distribution and function of immune cells and exerts
potent immunosuppressive effects. However, the mechanisms through which fasting …
potent immunosuppressive effects. However, the mechanisms through which fasting …
γδ-Enriched CAR-T cell therapy for bone metastatic castrate-resistant prostate cancer
JS Frieling, L Tordesillas, XE Bustos, MC Ramello… - Science …, 2023 - science.org
Immune checkpoint blockade has been largely unsuccessful for the treatment of bone
metastatic castrate-resistant prostate cancer (mCRPC). Here, we report a combinatorial …
metastatic castrate-resistant prostate cancer (mCRPC). Here, we report a combinatorial …