[HTML][HTML] Innate immunity: the first line of defense against SARS-CoV-2
MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions
K Dheda, T Perumal, H Moultrie, R Perumal… - The Lancet …, 2022 - thelancet.com
The global tuberculosis burden remains substantial, with more than 10 million people newly
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade …
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade …
[HTML][HTML] COVID-19 vaccines: where we stand and challenges ahead
G Forni, A Mantovani - Cell Death & Differentiation, 2021 - nature.com
In the eleven months elapsed since the identification of the SARS-CoV-2 virus and its
genome, an exceptional effort by the scientific community has led to the development of over …
genome, an exceptional effort by the scientific community has led to the development of over …
[HTML][HTML] Trained immunity—basic concepts and contributions to immunopathology
J Ochando, WJM Mulder, JC Madsen… - Nature Reviews …, 2023 - nature.com
Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …
Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections
P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …
[HTML][HTML] Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs
T Wang, J Zhang, Y Wang, Y Li, L Wang, Y Yu… - Nature …, 2023 - nature.com
Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious
functions. However, the potential function of virus-trained macrophages in antitumor …
functions. However, the potential function of virus-trained macrophages in antitumor …
100 years of Mycobacterium bovis bacille Calmette-Guérin
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …
Trained immunity: adaptation within innate immune mechanisms
J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
Trained immunity: reprogramming innate immunity in health and disease
S Bekkering, J Domínguez-Andrés… - Annual review of …, 2021 - annualreviews.org
Traditionally, the innate and adaptive immune systems are differentiated by their specificity
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …
Recent developments in the immunopathology of COVID‐19
There has been an important change in the clinical characteristics and immune profile of
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …